Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats

Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer’s disease in TgF344-AD rats

Abstract Background Imbalanced synaptic transmission appears to be an early driver in Alzheimer’s disease (AD) leading to brain network alterations. Early detection of altered synaptic transmission and insight into mechanisms causing early synaptic alterations would be valuable treatment strategies....

Full description

Bibliographic Details
Main Authors: Monica van den Berg, Mohit H. Adhikari, Marlies Verschuuren, Isabel Pintelon, Tamara Vasilkovska, Johan Van Audekerke, Stephan Missault, Loran Heymans, Peter Ponsaerts, Winnok H. De Vos, Annemie Van der Linden, Georgios A. Keliris, Marleen Verhoye
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Basal forebrain
Resting state functional MRI
Network dysfunction
Gliosis
Synaptic dysfunction
Online Access:https://doi.org/10.1186/s13195-022-01089-2

Internet

https://doi.org/10.1186/s13195-022-01089-2

Similar Items