Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization

Abstract Depression is a common chronic psychiatric illness, which is resistant to medical treatments. While melatonin may alleviate certain depression symptoms, evidence for its efficacy against core symptoms is lacking. Here, we tested a mechanism whereby melatonin rescues the behavioral outcomes...

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Bibliographic Details
Main Authors: Di Yao, Rong Li, Jiahuan Hao, Hongqing Huang, Xubiao Wang, Lusen Ran, Yuanyuan Fang, Yuqin He, Wei Wang, Xinghua Liu, Minghuan Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02614-z