Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma.

Tuberculosis (TB) granulomas are organized collections of immune cells comprised of macrophages, lymphocytes and other cells that form in the lung as a result of immune response to Mycobacterium tuberculosis (Mtb) infection. Formation and maintenance of granulomas are essential for control of Mtb in...

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Bibliographic Details
Main Authors: Mohammad Fallahi-Sichani, Matthew A Schaller, Denise E Kirschner, Steven L Kunkel, Jennifer J Linderman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2865521?pdf=render