L-Type Amino Acid Transporter-1 Overexpression and Melphalan Sensitivity in Barrett's Adenocarcinoma

L-Type Amino Acid Transporter-1 Overexpression and Melphalan Sensitivity in Barrett's Adenocarcinoma

The L-type amino acid transporter-1 (LAT-1) has been associated with tumor growth. Using cDNA microarrays, overexpression of LAT-1 was found in 87.5% (7/8) of esophageal adenocarcinomas relative to 12 Barrett's samples (33% metaplasia and 66% dysplasia) and was confirmed in 100% (28/28) of Barr...

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Bibliographic Details
Main Authors: Jules Lin, Duna A. Raoof, Dafydd G. Thomas, Joel K. Greenson, Thomas J. Giordano, Gregory S. Robinson, Maureen J. Bourner, Christopher T. Bauer, Mark B. Orringer, David G. Beer
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Esophageal adenocarcinoma
L-type amino acid transporter-1
amino acid transporters
melphalan
chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860480054X

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http://www.sciencedirect.com/science/article/pii/S147655860480054X

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