Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake

Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake

Abstract Background Laquinimod is an immunomodulatory drug under clinical investigation for the treatment of the progressive form of multiple sclerosis (MS) with both anti-inflammatory and neuroprotective effects. Excitotoxicity, a prominent pathophysiological feature of MS and of its animal model,...

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Bibliographic Details
Main Authors: Antonietta Gentile, Alessandra Musella, Francesca De Vito, Diego Fresegna, Silvia Bullitta, Francesca Romana Rizzo, Diego Centonze, Georgia Mandolesi
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Journal of Neuroinflammation
Subjects:
Excitotoxicity
Glutamate transporters
Experimental autoimmune encephalomyelitis
Cerebellum
Spontaneous excitatory post-synaptic currents
Neuroprotection
Online Access:http://link.springer.com/article/10.1186/s12974-017-1048-6

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http://link.springer.com/article/10.1186/s12974-017-1048-6

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