Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface

Novel Polymyxin-Inspired Peptidomimetics Targeting the SARS-CoV-2 Spike:hACE2 Interface

Though the bulk of the COVID-19 pandemic is behind, the search for effective and safe anti-SARS-CoV-2 drugs continues to be relevant. A highly pursued approach for antiviral drug development involves targeting the viral spike (S) protein of SARS-CoV-2 to prevent its attachment to the cellular recept...

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Bibliographic Details
Main Authors: Kelly Bugatti, Andrea Sartori, Lucia Battistini, Crescenzo Coppa, Emiel Vanhulle, Sam Noppen, Becky Provinciael, Lieve Naesens, Annelies Stevaert, Alessandro Contini, Kurt Vermeire, Franca Zanardi
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
cyclic peptides
protein–peptide interactions
antiviral agents
drug design
receptor-binding domain (RBD)
solid-phase peptide synthesis
Online Access:https://www.mdpi.com/1422-0067/24/10/8765

Internet

https://www.mdpi.com/1422-0067/24/10/8765

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