Similar Gastro-Intestinal Exposure to Florfenicol After Oral or Intramuscular Administration in Pigs, Leading to Resistance Selection in Commensal Escherichia coli

Similar Gastro-Intestinal Exposure to Florfenicol After Oral or Intramuscular Administration in Pigs, Leading to Resistance Selection in Commensal Escherichia coli

Florfenicol, which is licensed for veterinary use only, proves to be a potent antimicrobial for treatment of respiratory disease. However, the subsequent exposure of the gut microbiota to florfenicol is not well described. Hence, the effect of various administration protocols on both plasma and gast...

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Bibliographic Details
Main Authors: Joren De Smet, Filip Boyen, Siska Croubels, Geertrui Rasschaert, Freddy Haesebrouck, Patrick De Backer, Mathias Devreese
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
florfenicol
administration route
intestinal concentration
Escherichia coli
resistance selection
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01265/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01265/full

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