Identification of Crucial Amino Acid Residues for Antimicrobial Activity of Angiogenin 4 and Its Modulation of Gut Microbiota in Mice

Identification of Crucial Amino Acid Residues for Antimicrobial Activity of Angiogenin 4 and Its Modulation of Gut Microbiota in Mice

Angiogenin 4 bearing ribonuclease activity is an endogenous antimicrobial protein expressed in small and large intestine. However, the crucial amino acid residues responsible for the antibacterial activity of Ang4 and its impact on gut microbiota remain unknown. Here, we report the contribution of c...

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Bibliographic Details
Main Authors: Mst. Farzana Sultana, Maki Suzuki, Fumiya Yamasaki, Wataru Kubota, Kohta Takahashi, Hirohito Abo, Hiroto Kawashima
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Microbiology
Subjects:
angiogenin 4
antimicrobial peptide
ribonuclease
microbiome
microbiology
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.900948/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.900948/full

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