Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line

Urban PM2.5 Induces Cellular Toxicity, Hormone Dysregulation, Oxidative Damage, Inflammation, and Mitochondrial Interference in the HRT8 Trophoblast Cell Line

Objective: Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process. A first trimester trophoblast cell line (HTR-8/SVne...

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Bibliographic Details
Main Authors: Åsa Nääv, Lena Erlandsson, Christina Isaxon, Eleonor Åsander Frostner, Johannes Ehinger, Moa K. Sporre, Annette M. Krais, Bo Strandberg, Thomas Lundh, Eskil Elmér, Ebba Malmqvist, Stefan R. Hansson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Endocrinology
Subjects:
placenta
trophoblast cells
air pollution
PM2.5
preeclampsia
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00075/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00075/full

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