Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.

Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.

Elevated proteasome activity extends lifespan in model organisms such as yeast, worms and flies. This pro-longevity effect might be mediated by improved protein homeostasis, as this protease is an integral module of the protein homeostasis network. Proteasomes also regulate cellular processes throug...

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Bibliographic Details
Main Authors: Yanhua Yao, Scott Tsuchiyama, Ciyu Yang, Anne Laure Bulteau, Chong He, Brett Robison, Mitsuhiro Tsuchiya, Delana Miller, Valeria Briones, Krisztina Tar, Anahi Potrero, Bertrand Friguet, Brian K Kennedy, Marion Schmidt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004968&type=printable

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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1004968&type=printable

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