Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells

Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells

The mitochondrial genetic disorder, Leber&#8217;s hereditary optic neuropathy (LHON), is caused by a mutation in <i>MT-ND4</i> gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindnes...

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Bibliographic Details
Main Authors: Yi-Ping Yang, Phan Nguyen Nhi Nguyen, Tai-Chi Lin, Aliaksandr A. Yarmishyn, Wun-Syuan Chen, De-Kuang Hwang, Guang-Yuh Chiou, Tzu-Wei Lin, Chian-Shiu Chien, Ching-Yao Tsai, Shih-Hwa Chiou, Shih-Jen Chen, Chi-Hsien Peng, Chih-Chien Hsu
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
Leber’s hereditary optic neuropathy (LHON)
retina
retinal ganglion cell
glutamate
AMPA receptor
Online Access:https://www.mdpi.com/2073-4409/8/6/625

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https://www.mdpi.com/2073-4409/8/6/625

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