Local intraluminal delivery of a smooth muscle-targeted RNA ligand inhibits neointima growth in a porcine model of peripheral vascular disease

Local intraluminal delivery of a smooth muscle-targeted RNA ligand inhibits neointima growth in a porcine model of peripheral vascular disease

Anti-proliferative agents have been the primary therapeutic drug of choice to inhibit restenosis after endovascular treatment. However, recent safety and efficacy concerns for patients who underwent peripheral artery disease revascularization have demonstrated the need for alternative therapeutics....

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Bibliographic Details
Main Authors: Saami K. Yazdani, Beilei Lei, Claire V. Cawthon, Kathryn Cooper, Clifton Huett, Paloma H. Giangrande, Francis J. Miller, Jr.
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: oligonucleotides, therapies and applications
RNA
aptamer
cell-specific therapy
in vitro
cell migration
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122002037

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http://www.sciencedirect.com/science/article/pii/S2162253122002037

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