Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1–7) axis via NF-κB/MAPK pathway

Renin-angiotensin system inhibitors mitigate radiation pneumonitis by activating ACE2-angiotensin-(1–7) axis via NF-κB/MAPK pathway

Abstract Radiation pneumonitis (RP) affects both patients and physicians during radiation therapy for lung cancer. To date, there are no effective drugs for improving the clinical outcomes of RP. The activation of angiotensin-converting enzyme 2 (ACE2) improves experimental acute lung injury caused...

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Bibliographic Details
Main Authors: Changsheng Cong, Shiying Niu, Yifan Jiang, Xinhui Zhang, Wang Jing, Yawen Zheng, Xiaoyue Zhang, Guohai Su, Yueying Zhang, Meili Sun
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35412-0

Internet

https://doi.org/10.1038/s41598-023-35412-0

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