Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank

Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank

Abstract Background Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many individuals with detectable mCAs have no notable adverse outcomes, mCA-associated gene dosage alterations as well as clon...

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Bibliographic Details
Main Authors: Shu-Hong Lin, Derek W. Brown, Brandon Rose, Felix Day, Olivia W. Lee, Sairah M. Khan, Jada Hislop, Stephen J. Chanock, John R. B. Perry, Mitchell J. Machiela
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Cell & Bioscience
Subjects:
Mosaic loss of Y
Mosaic chromosomal alterations
Phenome-wide association study
PheWAS
UK Biobank
Online Access:https://doi.org/10.1186/s13578-021-00651-z

Internet

https://doi.org/10.1186/s13578-021-00651-z

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