Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases

Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases

Summary: Soluble HIV-1-envelope (Env) trimers elicit immune responses that target their solvent-exposed protein bases, the result of removing these trimers from their native membrane-bound context. To assess whether glycosylation could limit these base responses, we introduced sequons encoding poten...

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Bibliographic Details
Main Authors: Adam S. Olia, Cheng Cheng, Tongqing Zhou, Andrea Biju, Darcy R. Harris, Anita Changela, Hongying Duan, Vera B. Ivleva, Wing-Pui Kong, Li Ou, Reda Rawi, Yaroslav Tsybovsky, David J. Van Wazer, Angela R. Corrigan, Christopher A. Gonelli, Myungjin Lee, Krisha McKee, Sandeep Narpala, Sijy O’Dell, Danealle K. Parchment, Erik-Stephane D. Stancofski, Tyler Stephens, Ivy Tan, I-Ting Teng, Shuishu Wang, Qing Wei, Yongping Yang, Zhengrong Yang, Baoshan Zhang, Jan Novak, Matthew B. Renfrow, Nicole A. Doria-Rose, Richard A. Koup, Adrian B. McDermott, Jason G. Gall, Q. Paula Lei, John R. Mascola, Peter D. Kwong
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Molecular structure
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014803

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http://www.sciencedirect.com/science/article/pii/S2589004223014803

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