Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes

Abstract Background Affinity-optimized T cell receptor (TCR)-engineered lymphocytes targeting tumor antigens can mediate potent antitumor responses in cancer patients, but also bear substantial risks for off-target toxicities. Most preclinical studies have focused on T cell responses to antigen-spec...

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Bibliographic Details
Main Authors: Minh Ngoc Duong, Efe Erdes, Michael Hebeisen, Nathalie Rufer
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Immunotherapy
Preclinical study
CD8 T cells
NY-ESO-1 tumor antigen
TCR affinity optimization
TCR/CD3 complex
Online Access:http://link.springer.com/article/10.1186/s40425-019-0773-z

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http://link.springer.com/article/10.1186/s40425-019-0773-z

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