Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia

Bispecific NKG2D-CD3 and NKG2D-CD16 fusion proteins for induction of NK and T cell reactivity against acute myeloid leukemia

Abstract Background Monoclonal antibodies (mAbs) mediate their effects in great part by inducing ADCC of NK cells, and multiple efforts aim to increase this function by engineering mAbs optimized Fc-parts. Even more potent antitumor immunity can be induced by strategies to stimulate T cells with the...

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Bibliographic Details
Main Authors: Melanie Märklin, Ilona Hagelstein, Samuel P. Koerner, Kathrin Rothfelder, Martin S. Pfluegler, Andreas Schumacher, Ludger Grosse-Hovest, Gundram Jung, Helmut R. Salih
Format: Article
Language:English
Published: BMJ Publishing Group 2019-05-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
AML
NKG2DL
Bispecific
CD3
CD16
Leukemia
Online Access:http://link.springer.com/article/10.1186/s40425-019-0606-0

Internet

http://link.springer.com/article/10.1186/s40425-019-0606-0

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