The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1

The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1

Abstract The chromodomain helicase DNA-binding protein CHD8 is the most frequently mutated gene in autism spectrum disorder. Despite its prominent disease involvement, little is known about its molecular function in the human brain. CHD8 is a chromatin regulator which binds to the promoters of activ...

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Bibliographic Details
Main Authors: Bahareh Haddad Derafshi, Tamas Danko, Soham Chanda, Pedro J. Batista, Ulrike Litzenburger, Qian Yi Lee, Yi Han Ng, Anu Sebin, Howard Y. Chang, Thomas C. Südhof, Marius Wernig
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23614-x

Internet

https://doi.org/10.1038/s41598-022-23614-x

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