RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2

Abstract Chronic kidney disease (CKD) is thus deemed to a global health problem. Renal fibrosis, characterized by accumulation of extracellular matrix (ECM) components in the kidney, is considered a common pathway leading to CKD. Regulator of calcineurin1 (RCAN1), identified as a competitive endogen...

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Bibliographic Details
Main Authors: Jianjian Zhang, Hui Chen, Xiaodong Weng, Hao Liu, Zhiyuan Chen, Qin Huang, Lei Wang, Xiuheng Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00713-8