Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction

Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction

Abstract Background The autophagy adapter SQSTM1/p62 is crucial for maintaining homeostasis in various organs and cells due to its protein–protein interaction domains and involvement in diverse physiological and pathological processes. Vascular endothelium cells play a unique role in vascular biolog...

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Bibliographic Details
Main Authors: Jing Feng, Yan Li, Yu Zhang, Shengnan Sun, Jian Sun, Quanlin Xu, Xingzhao Ji, Yi Liu, Qiang Wan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
SQSTM1/p62
Endothelium cells
Fibrosis
Cardiac dysfunction
Fibronectin1
Lamininγ2
Online Access:https://doi.org/10.1186/s12967-024-04946-w

Internet

https://doi.org/10.1186/s12967-024-04946-w

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