Enhanced therapeutic potential of antibody fragment via IEDDA-mediated site-specific albumin conjugation

Enhanced therapeutic potential of antibody fragment via IEDDA-mediated site-specific albumin conjugation

Abstract Background The use of single-chain variable fragments (scFvs) for treating human diseases, such as cancer and immune system disorders, has attracted significant attention. However, a critical drawback of scFv is its extremely short serum half-life, which limits its therapeutic potential. Th...

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Bibliographic Details
Main Authors: Eun Byeol Go, Jae Hun Lee, Jeong Haeng Cho, Na Hyun Kwon, Jong-il Choi, Inchan Kwon
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Biological Engineering
Subjects:
Single-chain variable fragment
Therapeutic antibody
Human serum albumin
Site-specific conjugation
Half-life extension
Online Access:https://doi.org/10.1186/s13036-024-00418-3

Internet

https://doi.org/10.1186/s13036-024-00418-3

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