The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study
Background: Apolipoprotein E (APOE) ε4 is the only established risk gene for late-onset, sporadic Alzheimer’s disease (AD). Previous studies have provided inconsistent evidence for the effect of APOE ε4 status on the visuospatial working memory (VSWM).Objective: The aim was to investigate the effect...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-05-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00145/full |
| _version_ | 1828542916305354752 |
|---|---|
| author | Li-Hua Gu Jiu Chen Li-Juan Gao Hao Shu Zan Wang Duan Liu Yan-Na Yan Shi-Jiang Li Zhi-Jun Zhang Zhi-Jun Zhang |
| author_facet | Li-Hua Gu Jiu Chen Li-Juan Gao Hao Shu Zan Wang Duan Liu Yan-Na Yan Shi-Jiang Li Zhi-Jun Zhang Zhi-Jun Zhang |
| author_sort | Li-Hua Gu |
| collection | DOAJ |
| description | Background: Apolipoprotein E (APOE) ε4 is the only established risk gene for late-onset, sporadic Alzheimer’s disease (AD). Previous studies have provided inconsistent evidence for the effect of APOE ε4 status on the visuospatial working memory (VSWM).Objective: The aim was to investigate the effect of APOE ε4 on VSWM with an event-related potential (ERP) study in healthy controls (HC) and amnestic mild cognitive impairment (aMCI) patients.Methods: The study recorded 39 aMCI patients (27 APOE ε4 non-carriers and 12 APOE ε4 carriers) and their 43 matched controls (25 APOE ε4 non-carriers and 18 APOE ε4 carriers) with an 64-channel electroencephalogram. Participants performed an N-back task, a VSWM paradigm that manipulated the number of items to be stored in memory.Results: The present study detected reduced accuracy and delayed mean correct response time (RT) in aMCI patients compared to HC. P300, a positive component that peaks between 300 and 500 ms, was elicited by the VSWM task. In addition, aMCI patients showed decreased P300 amplitude at the central–parietal (CP1, CPz, and CP2) and parietal (P1, Pz, and P2) electrodes in 0- and 1-back task compared to HC. In both HC and aMCI patients, APOE ε4 carriers showed reduced P300 amplitude with respect to non-carriers, whereas no significant differences in accuracy or RT were detected between APOE ε4 carriers and non-carriers. Additionally, standardized low-resolution brain electromagnetic tomography analysis (s-LORETA) showed enhanced brain activation in the right parahippocampal gyrus (PHG) during P300 time range in APOE ε4 carriers with respect to non-carriers in aMCI patients.Conclusion: It demonstrated that P300 amplitude could predict VSWM deficits in aMCI patients and contribute to early detection of VSWM deficits in APOE ε4 carriers. |
| first_indexed | 2024-12-12T02:05:40Z |
| format | Article |
| id | doaj.art-f61b07b2349e4b36b707e2e8a2d2fc32 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T02:05:40Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f61b07b2349e4b36b707e2e8a2d2fc322022-12-22T00:42:04ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652017-05-01910.3389/fnagi.2017.00145237909The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials StudyLi-Hua Gu0Jiu Chen1Li-Juan Gao2Hao Shu3Zan Wang4Duan Liu5Yan-Na Yan6Shi-Jiang Li7Zhi-Jun Zhang8Zhi-Jun Zhang9Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast UniversityNanjing, ChinaDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast UniversityNanjing, ChinaDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast UniversityNanjing, ChinaDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast UniversityNanjing, ChinaDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast UniversityNanjing, ChinaDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast UniversityNanjing, ChinaDepartment of Psychology, Xinxiang Medical UniversityXinxiang, ChinaDepartment of Biophysics, Medical College of Wisconsin, MilwaukeeWI, United StatesDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast UniversityNanjing, ChinaDepartment of Psychology, Xinxiang Medical UniversityXinxiang, ChinaBackground: Apolipoprotein E (APOE) ε4 is the only established risk gene for late-onset, sporadic Alzheimer’s disease (AD). Previous studies have provided inconsistent evidence for the effect of APOE ε4 status on the visuospatial working memory (VSWM).Objective: The aim was to investigate the effect of APOE ε4 on VSWM with an event-related potential (ERP) study in healthy controls (HC) and amnestic mild cognitive impairment (aMCI) patients.Methods: The study recorded 39 aMCI patients (27 APOE ε4 non-carriers and 12 APOE ε4 carriers) and their 43 matched controls (25 APOE ε4 non-carriers and 18 APOE ε4 carriers) with an 64-channel electroencephalogram. Participants performed an N-back task, a VSWM paradigm that manipulated the number of items to be stored in memory.Results: The present study detected reduced accuracy and delayed mean correct response time (RT) in aMCI patients compared to HC. P300, a positive component that peaks between 300 and 500 ms, was elicited by the VSWM task. In addition, aMCI patients showed decreased P300 amplitude at the central–parietal (CP1, CPz, and CP2) and parietal (P1, Pz, and P2) electrodes in 0- and 1-back task compared to HC. In both HC and aMCI patients, APOE ε4 carriers showed reduced P300 amplitude with respect to non-carriers, whereas no significant differences in accuracy or RT were detected between APOE ε4 carriers and non-carriers. Additionally, standardized low-resolution brain electromagnetic tomography analysis (s-LORETA) showed enhanced brain activation in the right parahippocampal gyrus (PHG) during P300 time range in APOE ε4 carriers with respect to non-carriers in aMCI patients.Conclusion: It demonstrated that P300 amplitude could predict VSWM deficits in aMCI patients and contribute to early detection of VSWM deficits in APOE ε4 carriers.http://journal.frontiersin.org/article/10.3389/fnagi.2017.00145/fullapolipoprotein Eevent-related potentialamnestic mild cognitive impairmentvisuospatial working memoryP300 |
| spellingShingle | Li-Hua Gu Jiu Chen Li-Juan Gao Hao Shu Zan Wang Duan Liu Yan-Na Yan Shi-Jiang Li Zhi-Jun Zhang Zhi-Jun Zhang The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study Frontiers in Aging Neuroscience apolipoprotein E event-related potential amnestic mild cognitive impairment visuospatial working memory P300 |
| title | The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study |
| title_full | The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study |
| title_fullStr | The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study |
| title_full_unstemmed | The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study |
| title_short | The Effect of Apolipoprotein E ε4 (APOE ε4) on Visuospatial Working Memory in Healthy Elderly and Amnestic Mild Cognitive Impairment Patients: An Event-Related Potentials Study |
| title_sort | effect of apolipoprotein e ε4 apoe ε4 on visuospatial working memory in healthy elderly and amnestic mild cognitive impairment patients an event related potentials study |
| topic | apolipoprotein E event-related potential amnestic mild cognitive impairment visuospatial working memory P300 |
| url | http://journal.frontiersin.org/article/10.3389/fnagi.2017.00145/full |
| work_keys_str_mv | AT lihuagu theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT jiuchen theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT lijuangao theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT haoshu theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT zanwang theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT duanliu theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT yannayan theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT shijiangli theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT zhijunzhang theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT zhijunzhang theeffectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT lihuagu effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT jiuchen effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT lijuangao effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT haoshu effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT zanwang effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT duanliu effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT yannayan effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT shijiangli effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT zhijunzhang effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy AT zhijunzhang effectofapolipoproteinee4apoee4onvisuospatialworkingmemoryinhealthyelderlyandamnesticmildcognitiveimpairmentpatientsaneventrelatedpotentialsstudy |