Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related

Allosteric Modulation of GSK-3β as a New Therapeutic Approach in Limb Girdle Muscular Dystrophy R1 Calpain 3-Related

Limb-girdle muscular dystrophy R1 calpain 3-related (LGMDR1) is an autosomal recessive muscular dystrophy produced by mutations in the <i>CAPN3</i> gene. It is a rare disease and there is no cure or treatment for the disease while the pathophysiological mechanism by which the absence of...

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Bibliographic Details
Main Authors: Anabel Rico, Garazi Guembelzu, Valle Palomo, Ana Martínez, Ana Aiastui, Leire Casas-Fraile, Andrea Valls, Adolfo López de Munain, Amets Sáenz
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
LGMDR1
limb-girdle muscular dystrophy
<i>CAPN3</i>
tideglusib
VP0.7
GSK-3β
Online Access:https://www.mdpi.com/1422-0067/22/14/7367

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https://www.mdpi.com/1422-0067/22/14/7367

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