Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition

Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition

CDK8/19 kinases, which mediate transcriptional reprogramming, have become an active target for cancer drug discovery. Several small-molecule CDK8/19 inhibitors showed in vivo efficacy and two have entered clinical trials, with no significant toxicities reported. However, Clarke et al. (eLife 2016; 5...

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Bibliographic Details
Main Authors: Mengqian Chen, Jing Li, Jiaxin Liang, Zanshé S. Thompson, Katie Kathrein, Eugenia V. Broude, Igor B. Roninson
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
cdk8
cdk19
kinome profiling
zebrafish toxicity assays
stat1 serine phosphorylation
Online Access:https://www.mdpi.com/2073-4409/8/11/1413

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https://www.mdpi.com/2073-4409/8/11/1413

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