Potentiation of 17β-estradiol synthesis in the brain and elongation of seizure latency through dietary supplementation with docosahexaenoic acid

Abstract Several studies have shown that docosahexaenoic acid (DHA) attenuates epileptic seizures; however, the molecular mechanism by which it achieves this effect is still largely unknown. DHA stimulates the retinoid X receptor, which reportedly regulates the expression of cytochrome P450 aromatas...

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Bibliographic Details
Main Authors: Yasuhiro Ishihara, Kouichi Itoh, Miki Tanaka, Mayumi Tsuji, Toshihiro Kawamoto, Suguru Kawato, Christoph F. A. Vogel, Takeshi Yamazaki
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06630-0