Improving product quality and productivity of an antibody-based biotherapeutic using inverted frustoconical shaking bioreactors

Improving product quality and productivity of an antibody-based biotherapeutic using inverted frustoconical shaking bioreactors

The Chinese hamster ovarian (CHO) cells serve as a common choice in biopharmaceutical production, traditionally cultivated in stirred tank bioreactors (STRs). Nevertheless, the pursuit of improved protein quality and production output for commercial purposes demand exploration into new bioreactor ty...

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Bibliographic Details
Main Authors: Xuekun Wang, Jin Xu, Qingcheng Guo, Zhenhua Li, Jiawei Cao, Rongrong Fu, Mengjiao Xu, Xiang Zhao, Fugui Wang, Xinmeng Zhang, Taimin Dong, Xu Li, Weizhu Qian, Shen Hou, Lusha Ji, Dapeng Zhang, Huaizu Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
inverted frustoconical shaking bioreactor
stirred bioreactor
antibody-based biotherapeutic
scale-up production
productivity
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2024.1352098/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1352098/full

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