The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair

Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using a Gli1 reporter line, we found that Gli1+ cells contribute to the development of meniscus horns from 2 weeks of age. In adult mice, Gli1+ cells resided at the superficial layer o...

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Bibliographic Details
Main Authors: Yulong Wei, Hao Sun, Tao Gui, Lutian Yao, Leilei Zhong, Wei Yu, Su-Jin Heo, Lin Han, Nathaniel A Dyment, Xiaowei Sherry Liu, Yejia Zhang, Eiki Koyama, Fanxin Long, Miltiadis H Zgonis, Robert L Mauck, Jaimo Ahn, Ling Qin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
Gli1
mesenchymal progenitor
lineage tracing
meniscus injury
osteoarthritis
Online Access:https://elifesciences.org/articles/62917

Internet

https://elifesciences.org/articles/62917

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