The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation

Abstract Objectives The complement system is an important component of innate immunity. The alternative pathway (AP) amplification loop is considered an essential feed forward mechanism for complement activation. However, the role of the AP in classical pathway (CP) activation has only been studied...

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Bibliographic Details
Main Authors: Esther CW deBoer, Astrid JF Thielen, Jeroen D Langereis, Angela Kamp, Mieke C Brouwer, Nienke Oskam, Marlieke L Jongsma, April J Baral, Robbert M Spaapen, Sacha Zeerleder, Gestur Vidarsson, Theo Rispens, Diana Wouters, Richard B Pouw, Ilse Jongerius
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Clinical & Translational Immunology
Subjects:
alternative pathway
amplification loop
antibodies
autoimmune haemolytic anaemia
classical pathway
complement activation
Online Access:https://doi.org/10.1002/cti2.1436

Internet

https://doi.org/10.1002/cti2.1436

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