Treprostinil inhibits proliferation and extracellular matrix deposition by fibroblasts through cAMP activation

Treprostinil inhibits proliferation and extracellular matrix deposition by fibroblasts through cAMP activation

Abstract Idiopathic pulmonary fibrosis (IPF) is characterized by peripheral lung fibrosis and increased interstitial extracellular matrix (ECM) deposition. In IPF, tumor growth factor (TGF)-β1 which is the major stimulus of ECM deposition, and platelet derived growth factor (PDGF)-BB is a potent sti...

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Bibliographic Details
Main Authors: Christopher Lambers, Michael Roth, Peter Jaksch, Gabriella Muraközy, Michael Tamm, Walter Klepetko, Bahil Ghanim, Feng Zhao
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-19294-1

Internet

https://doi.org/10.1038/s41598-018-19294-1

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