COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES
There are several methods for solving the problem of an adequate dosage form for the hydrophobic and poorly soluble pharmaceutical substances which comprise a structure modification, preparation of solid dispersion systems, a change in pH, the use of cosolvents and solubilizers introduction of subst...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/83 |
| _version_ | 1797875072493420544 |
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| author | I. D. Gulyakin L. L. Nikolaeva N. A. Oborotova M. V. Dmitrieva A. V. Lantsova E. V. Sanarova O. L. Orlova A. P. Polozkova H. I. Lavrukhin N. D. Bunyatyan |
| author_facet | I. D. Gulyakin L. L. Nikolaeva N. A. Oborotova M. V. Dmitrieva A. V. Lantsova E. V. Sanarova O. L. Orlova A. P. Polozkova H. I. Lavrukhin N. D. Bunyatyan |
| author_sort | I. D. Gulyakin |
| collection | DOAJ |
| description | There are several methods for solving the problem of an adequate dosage form for the hydrophobic and poorly soluble pharmaceutical substances which comprise a structure modification, preparation of solid dispersion systems, a change in pH, the use of cosolvents and solubilizers introduction of substances in the formulation of lipid nature and complexation. In this review, special attention is paid to the preparation of nanostructured dosage form for these classes of drugs. Are examples of drugs used successfully in clinical practice the development of which applied these methods. |
| first_indexed | 2024-04-10T01:41:54Z |
| format | Article |
| id | doaj.art-f62bee0a608c4073866dcc9221c24606 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:41:54Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-f62bee0a608c4073866dcc9221c246062023-03-13T09:13:56ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102525983COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCESI. D. Gulyakin0L. L. Nikolaeva1N. A. Oborotova2M. V. Dmitrieva3A. V. Lantsova4E. V. Sanarova5O. L. Orlova6A. P. Polozkova7H. I. Lavrukhin8N. D. Bunyatyan9ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина»ГБОУ ВПО Первый МГМУ им. И.М. СеченоваThere are several methods for solving the problem of an adequate dosage form for the hydrophobic and poorly soluble pharmaceutical substances which comprise a structure modification, preparation of solid dispersion systems, a change in pH, the use of cosolvents and solubilizers introduction of substances in the formulation of lipid nature and complexation. In this review, special attention is paid to the preparation of nanostructured dosage form for these classes of drugs. Are examples of drugs used successfully in clinical practice the development of which applied these methods.https://www.pharmjournal.ru/jour/article/view/83сорастворителисолюбилизаторытвердые дисперсные системыкомплексообразованиенаносистемы |
| spellingShingle | I. D. Gulyakin L. L. Nikolaeva N. A. Oborotova M. V. Dmitrieva A. V. Lantsova E. V. Sanarova O. L. Orlova A. P. Polozkova H. I. Lavrukhin N. D. Bunyatyan COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES Разработка и регистрация лекарственных средств сорастворители солюбилизаторы твердые дисперсные системы комплексообразование наносистемы |
| title | COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES |
| title_full | COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES |
| title_fullStr | COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES |
| title_full_unstemmed | COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES |
| title_short | COMMON METHODS INCREASING THE SOLUBILITY OF POORLY SOLUBLE HYDROPHOBIC SUBSTANCES |
| title_sort | common methods increasing the solubility of poorly soluble hydrophobic substances |
| topic | сорастворители солюбилизаторы твердые дисперсные системы комплексообразование наносистемы |
| url | https://www.pharmjournal.ru/jour/article/view/83 |
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