Alpha-1,3-galactosyltransferase-deficient miniature pigs produced by serial cloning using neonatal skin fibroblasts with loss of heterozygosity

Alpha-1,3-galactosyltransferase-deficient miniature pigs produced by serial cloning using neonatal skin fibroblasts with loss of heterozygosity

Objective Production of alpha-1,3-galactosyltransferase (αGT)-deficient pigs is essential to overcome xenograft rejection in pig-to-human xenotransplantation. However, the production of such pigs requires a great deal of cost, time, and labor. Heterozygous αGT knockout pigs should be bred at least f...

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Bibliographic Details
Main Authors: Young June Kim, Kwang Sung Ahn, Minjeong Kim, Min Ju Kim, Jin Seop Ahn, Junghyun Ryu, Soon Young Heo, Sang-Min Park, Jee Hyun Kang, You Jung Choi, Hosup Shim
Format: Article
Language:English
Published: Asian-Australasian Association of Animal Production Societies 2017-03-01
Series:Asian-Australasian Journal of Animal Sciences
Subjects:
Nuclear Transfer
Alpha-1
3-galactosyltransferase
Gene Targeting
Loss of heterozygosity
Pig
Online Access:http://www.ajas.info/upload/pdf/ajas-30-3-439.pdf

Internet

http://www.ajas.info/upload/pdf/ajas-30-3-439.pdf

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