N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

N6-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma

Abstract Background Sunitinib resistance can be classified into primary and secondary resistance. While accumulating research has indicated several underlying factors contributing to sunitinib resistance, the precise mechanisms in renal cell carcinoma are still unclear. Methods RNA sequencing and m6...

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Bibliographic Details
Main Authors: Yuanlei Chen, Zeyi Lu, Chao Qi, Chenhao Yu, Yang Li, Wang Huan, Ruyue Wang, Wenqin Luo, Danyang Shen, Lifeng Ding, Liangliang Ren, Haiyun Xie, Dingwei Xue, Mingchao Wang, Kangxin Ni, Liqun Xia, Jun Qian, Gonghui Li
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Cancer
Subjects:
Sunitinib-resistance
TRAF1
METTL14
N6-methyladenosine
RCC
Online Access:https://doi.org/10.1186/s12943-022-01549-1

Internet

https://doi.org/10.1186/s12943-022-01549-1

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