A Predictive Model of Adaptive Resistance to BRAF/MEK Inhibitors in Melanoma

A Predictive Model of Adaptive Resistance to BRAF/MEK Inhibitors in Melanoma

The adaptive acquisition of resistance to BRAF and MEK inhibitor-based therapy is a common feature of melanoma cells and contributes to poor patient treatment outcomes. Leveraging insights from a proteomic study and publicly available transcriptomic data, we evaluated the predictive capacity of a ge...

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Bibliographic Details
Main Authors: Emmanuelle M. Ruiz, Solomon A. Alhassan, Youssef Errami, Zakaria Y. Abd Elmageed, Jennifer S. Fang, Guangdi Wang, Margaret A. Brooks, Joe A. Abi-Rached, Emad Kandil, Mourad Zerfaoui
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
BRAF/MEK inhibitors
aggressiveness
risk stratification
resistance
biomarkers
Online Access:https://www.mdpi.com/1422-0067/24/9/8407

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https://www.mdpi.com/1422-0067/24/9/8407

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