The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjögren’s Syndrome

The Transcriptome of Paired Major and Minor Salivary Gland Tissue in Patients With Primary Sjögren’s Syndrome

BackgroundWhile all salivary glands (SGs) can be involved in primary Sjögren’s syndrome (pSS), their respective role in pathogenesis remains unclear. Our objective was to assess immunopathway activation in paired parotid and labial gland tissue from biopsy-positive and biopsy-negative pSS and non-SS...

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Bibliographic Details
Main Authors: Gwenny M. Verstappen, Lu Gao, Sarah Pringle, Erlin A. Haacke, Bert van der Vegt, Silvia C. Liefers, Vishal Patel, Yanhua Hu, Sumanta Mukherjee, Julie Carman, Laurence C. Menard, Frederik K. L. Spijkervet, Arjan Vissink, Hendrika Bootsma, Frans G. M. Kroese
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
Sjogren’s syndrome
autoimmune disease
transcriptome (RNA-seq)
B cell abnormalities
T cell activation, salivary gland
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.681941/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.681941/full

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