Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions

Abstract Throughout adult life, most lineages of blood cells, including immune cells, are generated from hematopoietic stem cells (HSCs) in the bone marrow. HSCs are thought to require special microenvironments, termed niches, for their maintenance in the bone marrow; however, the identity of the HS...

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Bibliographic Details
Main Author: Yoshiki Omatsu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Inflammation and Regeneration
Subjects:
Online Access:https://doi.org/10.1186/s41232-023-00267-5