CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

Abstract Osteoarthritis is a prevalent age-related disease characterized by dysregulation of extracellular matrix metabolism, lipid metabolism, and upregulation of senescence-associated secretory phenotypes. Herein, we clarify that CircRREB1 is highly expressed in secondary generation chondrocytes a...

Full description

Bibliographic Details
Main Authors: Zhe Gong, Jinjin Zhu, Junxin Chen, Fan Feng, Haitao Zhang, Zheyuan Zhang, Chenxin Song, Kaiyu Liang, Shuhui Yang, Shunwu Fan, Xiangqian Fang, Shuying Shen
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40975-7

Internet

https://doi.org/10.1038/s41467-023-40975-7

Similar Items