Paternal p,p′-DDE exposure and pre-pubertal high-fat diet increases the susceptibility to fertility impairment and sperm Igf2 DMR2 hypo-methylation in male offspring

Paternal p,p′-DDE exposure and pre-pubertal high-fat diet increases the susceptibility to fertility impairment and sperm Igf2 DMR2 hypo-methylation in male offspring

The hypothesis of paternal origins of health and disease (POHaD) indicates that paternal exposure to adverse environment could alter the epigenetic modification in germ line, increasing the disease susceptibility in offspring or even in subsequent generations. p,p′-Dichlorodiphenyldichloroethylene (...

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Bibliographic Details
Main Authors: Liping Lu, Yuzhou Cheng, Wei Wu, Lijun Wang, Shuqi Li, Qianyu Li, Liangjing Chen, Jianyun Zhang, Rong Chen, Xiaohua Tan, Yu Hong, Lei Yang, Yang Song
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Paternal exposure
P,p′-DDE
Male fertility
Igf2
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324000745

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http://www.sciencedirect.com/science/article/pii/S0147651324000745

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