Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death

Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death

Despite its effectiveness in treating inflammatory diseases and various malignancies, methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased oxidative stress and inflammation, limiting its clinical use. Herein, we looked into the effect of punicalagin (PU), a polyphenolic...

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Bibliographic Details
Main Authors: Alayn’ Al-marddyah A. Al-khawalde, Mohammad H. Abukhalil, Muthana M. Jghef, Manal A. Alfwuaires, Fatima S. Alaryani, Saleem H. Aladaileh, Abdulmohsen I. Algefare, Shaik Karimulla, Fawaz Alasmari, Hammad Khalifeh Aldal’in, Abdulkareem A. Alanezi, Osama Y. Althunibat
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
methotrexate
oxidative stress
Nrf2
hepatotoxicity
punicalagin
Online Access:https://www.mdpi.com/1422-0067/23/20/12334

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https://www.mdpi.com/1422-0067/23/20/12334

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