Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation

Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation

Abstract Objective Obesity represents a significant global health challenge characterized by chronic low-grade inflammation and metabolic dysregulation. The hypothalamus, a key regulator of energy homeostasis, is particularly susceptible to obesity’s deleterious effects. This study investigated the...

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Bibliographic Details
Main Authors: Nicolás Albornoz, Javiera Álvarez-Indo, Adely de la Peña, Eloisa Arias-Muñoz, Alanis Coca, Fabián Segovia-Miranda, Bredford Kerr, Mauricio Budini, Alfredo Criollo, María A. García-Robles, Eugenia Morselli, Andrea Soza, Patricia V. Burgos
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Journal of Neuroinflammation
Subjects:
Obesity
Immunoproteasome
Hypothalamus
Neurons
Insulin-glucose axis
Autophagy
Online Access:https://doi.org/10.1186/s12974-024-03154-z

Internet

https://doi.org/10.1186/s12974-024-03154-z

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