Evolution of intra-tumoral heterogeneity across different pathological stages in papillary thyroid carcinoma

Evolution of intra-tumoral heterogeneity across different pathological stages in papillary thyroid carcinoma

Abstract Background Intra-tumor heterogeneity (ITH) results from the continuous accumulation of mutations during disease progression, thus impacting patients’ clinical outcome. How the ITH evolves across papillary thyroid carcinoma (PTC) different tumor stages is lacking. Methods We used the whole-e...

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Bibliographic Details
Main Authors: Ornella Affinito, Francesca Maria Orlandella, Neila Luciano, Marco Salvatore, Giuliana Salvatore, Monica Franzese
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cancer Cell International
Subjects:
Papillary thyroid cancer
Tumor heterogeneity
TCGA-THCA
Tumor stages
Mutational signatures
Prognosis
Online Access:https://doi.org/10.1186/s12935-022-02680-1

Internet

https://doi.org/10.1186/s12935-022-02680-1

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