Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations

Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations

The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy Chinese subjects and evaluate the optimal dosage regimens of doripenem. A randomized, single-dose, three-period, self-crossover controlled extended-infusion clinical trial was conducted with 12 healthy Chinese...

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Bibliographic Details
Main Authors: Yu Wang, Xiaofen Liu, Kun Li, Yaxin Fan, Jicheng Yu, Hailan Wu, Yi Li, Xiaojie Wu, Beining Guo, Xin Li, Jiali Hu, Jufang Wu, Guoying Cao, Jing Zhang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antibiotics
Subjects:
doripenem
healthy Chinese subjects
prolonging infusion time
pharmacokinetics
Monte Carlo simulation
Online Access:https://www.mdpi.com/2079-6382/11/7/958

Internet

https://www.mdpi.com/2079-6382/11/7/958

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