Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor preventing metastasis in triple-negative breast cancer cells

Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor preventing metastasis in triple-negative breast cancer cells

Enhancer of zeste homolog 2 (EZH2) is activated in breast cancer, particularly in triple-negative breast cancer (TNBC), and is critical for cell invasion. It interacts with embryonic ectoderm development (EED) in maintaining cancer stem cells (CSC) and epithelial-mesenchymal transition (EMT) propert...

Full description

Bibliographic Details
Main Authors: Shasha Cheng, Guan-Jun Yang, Wanhe Wang, Ying-Qi Song, Chung-Nga Ko, Quanbin Han, Dik-Lung Ma, Chung-Hang Leung
Format: Article
Language:English
Published: Compuscript Ltd 2022-05-01
Series:Acta Materia Medica
Subjects:
enhancer of zeste homolog 2 (ezh2)
embryonic ectoderm development (eed)
polycomb repressive complex (prc2)
protein-protein interaction
triple-negative breast cancer
metastasis
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0006

Internet

https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0006

Similar Items