Evaluation of Human Mesenchymal Stromal Cells as Carriers for the Delivery of Oncolytic HAdV-5 to Head and Neck Squamous Cell Carcinomas

Evaluation of Human Mesenchymal Stromal Cells as Carriers for the Delivery of Oncolytic HAdV-5 to Head and Neck Squamous Cell Carcinomas

Human multipotent mesenchymal stromal cells (hMSCs) are of significant therapeutic interest due to their ability to deliver oncolytic adenoviruses to tumors. This approach is also investigated for targeting head and neck squamous cell carcinomas (HNSCCs). HAdV-5-HexPos3, a recently reported capsid-m...

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Bibliographic Details
Main Authors: Robin Nilson, Lea Krutzke, Frederik Wienen, Markus Rojewski, Philip Helge Zeplin, Wolfgang Funk, Hubert Schrezenmeier, Stefan Kochanek, Astrid Kritzinger
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
human mesenchymal stromal cells
mesenchymal stem cells
carrier cells
human head and neck squamous cell carcinoma
migration
oncolytic adenovirus
Online Access:https://www.mdpi.com/1999-4915/15/1/218

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https://www.mdpi.com/1999-4915/15/1/218

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