Involvement of classic and alternative non-homologous end joining pathways in hematologic malignancies: targeting strategies for treatment

Involvement of classic and alternative non-homologous end joining pathways in hematologic malignancies: targeting strategies for treatment

Abstract Chromosomal translocations are the main etiological factor of hematologic malignancies. These translocations are generally the consequence of aberrant DNA double-strand break (DSB) repair. DSBs arise either exogenously or endogenously in cells and are repaired by major pathways, including n...

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Bibliographic Details
Main Authors: Mohsen Valikhani, Elahe Rahimian, Seyed Esmaeil Ahmadi, Rouzbeh Chegeni, Majid Safa
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Experimental Hematology & Oncology
Subjects:
Double-strand break
Double-strand break repair
Non-homologous end-joining
Alternative end-joining pathways
Hematologic malignancies
Targeted therapy
Online Access:https://doi.org/10.1186/s40164-021-00242-1

Internet

https://doi.org/10.1186/s40164-021-00242-1

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