GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis

GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease with a complex etiology. Monocyte-derived macrophages (MDMs) infiltration are associated with RA severity. We have reported the deletion of G-protein-coupled receptor kinase 2 (GRK2) reprograms macrophages toward an anti-inflammatory phenotype by re...

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Bibliographic Details
Main Authors: Xuezhi Yang, Yingjie Zhao, Qi Wei, Xuemin Zhu, Luping Wang, Wankang Zhang, Xiaoyi Liu, Jiajie Kuai, Fengling Wang, Wei Wei
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
GRK2
Monocyte-derived macrophages
Rheumatoid arthritis
PPARγ
Flt-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003660

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http://www.sciencedirect.com/science/article/pii/S2211383523003660

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