Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression
While it is well-established that distal hypoxia response elements (HREs) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HREs has not been described so far. Hepatic Epo expression is regulated by a HRE...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2019-12-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/9583 |