Mitochondrial toxicants in Xian-Ling-Gu-Bao induce liver injury by regulating the PI3K/mTOR signaling pathway: an in vitro study

Mitochondrial toxicants in Xian-Ling-Gu-Bao induce liver injury by regulating the PI3K/mTOR signaling pathway: an in vitro study

Abstract Background Drug-induced mitochondrial toxicity is thought to be a common mechanism of drug hepatotoxicity. Xian-Ling-Gu-Bao (XLGB) oral preparation is a commonly used drug for osteoporosis in China. Classical safety evaluation studies have shown that the entire preparation and six Chinese h...

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Bibliographic Details
Main Authors: Shujuan Piao, Hongwei Lin, Xia Tao, Wansheng Chen
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Drug-induced liver injury
Xian-Ling-Gu-Bao
Mitochondrial dysfunction
Bioenergetics
Apoptosis
Autophagy
Online Access:https://doi.org/10.1186/s12906-022-03798-5

Internet

https://doi.org/10.1186/s12906-022-03798-5

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