Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells

Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells

BACKGROUND Once in the pulmonary alveoli, Mycobacterium tuberculosis (Mtb) enters into contact with alveolar macrophages and dendritic cells (DCs). DCs represent the link between the innate and adaptive immune system owing to their capacity to be both a sentinel and an orchestrator of the antigen-s...

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Bibliographic Details
Main Authors: Ana Gabriela Ramos-Martinez, Monica Alejandra Valtierra-Alvarado, Mariana Haydee Garcia-Hernandez, Rogelio Hernandez-Pando, Julio Enrique Castañeda-Delgado, Céline Cougoule, Bruno Rivas-Santiago, Olivier Neyrolles, Jose Antonio Enciso-Moreno, Geanncarlo Lugo-Villarino, Carmen Judith Serrano
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ)
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
tuberculosis
dendritic cells
virulence
apoptosis
antigen presentation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100342&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100342&lng=en&tlng=en

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