Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

ABSTRACT A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying mechanisms or the potential role of Fc-mediated e...

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Bibliographic Details
Main Authors: M. Muenchhoff, A. W. Chung, J. Roider, Anne-Sophie Dugast, Simone Richardson, Henrik Kløverpris, Alasdair Leslie, Thumbi Ndung’u, Penny Moore, Galit Alter, Philip J. R. Goulder
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mSphere
Subjects:
Fc effector functions
Fc glycosylation
HIV
broadly neutralizing antibodies (bnAbs)
nonneutralizing antibodies
pediatric
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00880-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.00880-20

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