Highly Efficient Generation of Transgenically Augmented CAR NK Cells Overexpressing CXCR4

Highly Efficient Generation of Transgenically Augmented CAR NK Cells Overexpressing CXCR4

Natural killer (NK) cells are a noteworthy lymphocyte subset in cancer adoptive cell therapy. NK cells initiate innate immune responses against infections and malignancies with natural cytotoxicity, which is independent of foreign antigen recognition. Based on these substantive features, genetically...

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Bibliographic Details
Main Authors: Arezoo Jamali, Jamshid Hadjati, Zahra Madjd, Hamid Reza Mirzaei, Frederic B. Thalheimer, Shiwani Agarwal, Halvard Bonig, Evelyn Ullrich, Jessica Hartmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
natural killer cell
chimeric antigen receptor
immunotherapy
fully human CAR
CD19
huCAR19
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02028/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02028/full

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